Characteristics of the dual nature of the p27 protein in oral leukoplakias and cancer

Abstract Dysregulation of the cell cycle is an important factor in a potentially malignant oral disorder. There have not been many studies on role regulator p27 non-homogenous leukoplakia. The aim our study was to characterise protein homogenous and leukoplakias (OL), comparison with healthy mucosa squamous carcinoma tissues. current included 25 patients OL, 15 cases carcinoma, samples mucosa, both as groups. Immunohistochemical antigen expression determined by standard EnView imaging system. level nodular verrucous leukoplakia lower than OL but higher erythroleukoplakia. statistically significant difference ( p < 0.05) between OL. significantly amount positive cells cancer 0.0001); however, its intracytoplasmic presence diagnosed. Our proved instability dual nature OSCC, therefore, it can be used predictive marker for clinical course these conditions.